Small Animal Internal Medicine
NEWS - February 2013
Small Animal Internal Medicine
NEWS – February 2013
The MSU-CVM Small Animal Internal Medicine service currently has five faculty members providing specialist-level clinical service to the local veterinary community. Drs. John Thomason, Andrew Mackin, Kari Lunsford, Patty Lathan and Todd Archer are regularly scheduled on clinical duty to meet local referral needs. The Medicine service routinely handles internal medicine and oncology referrals from Mississippi, Alabama and Tennessee, with occasional cases from as far away as Arkansas and Louisiana. Drs. Thomason and Lunsford have taken the lead in managing our steadily growing oncology caseload with the assistance of our Medicine/Oncology Specialty intern, Dr. Alyssa Sullivant (MSU 2007), and MSU is currently advertising for a boarded oncologist to facilitate the continued expansion of the clinical and research components of our oncology program. Dr. Taya Marquardt (WSU 2008), who was our Oncology Specialty intern from 2009 to 2010, and then a Clinical Instructor in Oncology at MSU from 2010 to 2011, will soon be commencing an oncology residency at Auburn University in July 2013, and will then return to the MSU-CVM to join our faculty as an oncologist.
American College of Veterinary Internal Medicine:
Drs. Lathan, Archer, Thomason and Lunsford all presented lectures on the main scientific program at the ACVIM Forum in New Orleans in 2012. Dr. Lathan, in her role as secretary/treasurer of the Society for Comparative Endocrinology, helped run the SCE Business Meeting at the ACVIM Forum, and also served as a member of the ACVIM Credentials Committee. Drs. Lathan and Mackin also served as members on several ACVIM examination rating committees (General and Certifying Exams, respectively). Dr. Archer serves on the ACVIM Foundation Board of Directors, and is also a member of the Foundation’s Scientific Review Committee.
House Officers and Graduate Students:
Senior Medicine resident Dr. Jill Manion, will be completing her residency in July. She has just completed work on her Masters project ‘Pharmacokinetics of Inhaled Heparin in the Dog’. On a personal note, Jill recently gave birth to a baby girl, Brynn. Congratulations to Jill and Ryan! Second year resident Dr. Jillian Haines is currently in the midst of data collection for her Masters research project ‘Characterization of Canine Aspirin Responsiveness’. First year resident Dr. Claire Fellman continues to work on her concurrent PhD based on pharmacodynamic assessment of the effects of cyclosporine in T-cells, and is also in the process of developing a dual residency program with the American College of Veterinary Clinical Pharmacology.
Current Medicine/Oncology intern Dr. Alyssa Sullivant will be moving on to do a Medicine residency here at MSU in July, and has already commenced preliminary work on her Masters project exploring the nature of histamine receptors within the canine gastrointestinal tract. Several of MSU-CVM’s current small animal interns recently successfully matched, through the VIRMP match program, into medicine residencies elsewhere: Dr. Eileen Seage will be doing her residency training at the University of Pennsylvania, and Dr. Katrina Stewart will be moving to Purdue University for her residency. Drs. Seage and Stewart are following in the footsteps of several of our recent past interns who are currently in medicine residencies: Dr. Alicia Dudley at The Ohio State University, Dr. Andrea Dedeaux at Louisiana State University, and Dr. Brian Geesaman at the University of Wisconsin.
Our DVM/PhD graduate students, Shauna Trichler and Caitlin Riggs, are currently in the second year of their PhD programs, and will be entering the DVM professional curriculum in the middle of the year. Shauna is working with Drs. Lunsford, Thomason and Camilo Bulla in the Comparative Platelet Research/Diagnostic Laboratory, and Caitlin is working on the effects of cyclosporine on of T-cell cytokine expression as measured by qRT-PCR analysis with Drs. Archer, Mackin, Fellman and Bulla.
Faculty Updates:
Dr. Todd Archer, Assistant Professor in Small Animal Internal Medicine, was appointed to the ACVIM Foundation Board of Directors in 2012, and also serves on the Scientific Review Committee for the ACVIM Foundation. He also continues to serve on the Executive Board of the Mississippi Veterinary Medical Association. Dr. Archer successfully defended and completed his Masters of Veterinary Science degree in mid-2012. He was an invited speaker at 2012 ACVIM Forum within the pharmacology track of the main scientific program, presenting the topic ‘The Immunomodulatory Properties of Cyclosporine’. This past year, Dr. Archer also developed a new senior elective course, Small Animal Clinical Hematology and Immunology. He was an invited speaker at the South Carolina Association of Veterinarians Annual Conference, covering various internal medicine topics. He will soon be speaking at the West Virginia Veterinary Medical Association Annual Meeting as well as the Southeast Veterinary Conference in Myrtle Beach. Dr. Archer served as a course instructor for a Veterinary Information Network Advanced Hematology course, and also helped Dr. Lathan run another VIN course discussing canine hyperadrenocorticism.
In 2012, Dr. John Thomason joined our graduate faculty as Assistant Professor in Small Animal Internal Medicine, moving from his previous position as an Assistant Research Professor here at MSU. He also completed his Masters of Veterinary Science degree in 2012. Dr. Thomason presented a comprehensive review on the topic ‘Monitoring Platelet Function During Anti-Platelet Therapy’ for the main scientific program of the 2012 ACVIM Forum in New Orleans, Louisiana, and has also been invited to speak at the upcoming ACVIM Forum in Seattle on the subject ‘Aspirin Resistance: What Do We Really Know?’. Dr. Thomason recently spoke on various hematologic and oncologic topics at the Tennessee Valley Veterinary Conference in Florence, Alabama and at the Tuscaloosa County Veterinary Medical Association Summer Meeting in Alabama. He continues to serve as course coordinator for the popular Practical Clinical Oncology senior elective course.
Dr. Patty Lathan, Assistant Professor in Small Animal Internal Medicine, recently represented MSU-CVM in a visit to Grenada in order to promote our clinical program to St. George’s University veterinary school students considering North American sites for their final clinical year. Back here in the US, Dr. Lathan has continued to expand her endocrinology clinical and research focus. At the 2012 ACVIM Forum in New Orleans, she presented ‘Understanding ACTH Stimulation Tests’ in the main scientific program. She also recently provided continuing education lectures on various endocrine topics for the West Virginia Veterinary Medical Association, and is planning to speak on similar topics at the upcoming Southeast Veterinary Conference in Myrtle Beach. In early 2013, she had a book chapter published on her favorite condition, hypoadrenocorticism, in the new Clinical Endocrinology of Companion Animals textbook. She and Dr. Archer also provided an online course on canine hyperadrenocorticism for the Veterinary Information Network. Dr. Lathan’s Comparative Endocrinology course has continued to be a very popular elective course for our clinical students, and each year has continued to produce a new crop of entertaining student-directed endocrine videos.
Endocrine videos:
Insulinoma: http://www.youtube.com/watch?v=FjXtH2_YD18
Diabetes Insipidus: https://www.youtube.com/watch?v=ElEONHSKKSY
Hypocalcemia: http://www.youtube.com/watch?v=wBIrw0Ni8NI
Hyperparathyroidism: https://www.youtube.com/watch?v=XsTVBq8M3V4
Dr. Kari Lunsford, Assistant Professor in Small Animal Internal Medicine, serves as Program Coordinator of the MSU-CVM Translational Biomedical Research center (TRBc). The mandate of the TRBc is to build and coordinate MSU-CVM research relationships with industry and with institutional partners. Dr. Lunsford also shares responsibility with Dr. Camilo Bulla in the Department of Pathobiology & Population Medicine for developing the MSU-CVM Comparative Platelet Research/Diagnostic Laboratory. Dr. Lunsford has been working to develop collaborative international research partnerships, and recently visited Brazil to speak as an invited lecturer on various hemostasis and oncologic research topics in the graduate curriculum of the School of Veterinary Medicine at the Universidade Estadual Paulista in Sáo Paulo. Dr. Lunsford spoke on the main scientific program at the 2012 ACVIM Forum in New Orleans on the topic ‘To Clot or Not to Clot: Disordered Hemostasis and What to Do About It’.
Dr. Andrew Mackin, Professor and Dr. Hugh G. Ward Endowed Chair of Small Animal Veterinary Medicine, has in the past year lectured on various hematology and hemostasis topics at the Western Veterinary Conference in Las Vegas, the Chicago Veterinary Medical Association, the Connecticut Veterinary Medical Association and North American Veterinary Conference in Orlando, and for 2013 has also been invited to speak again at the Western Veterinary Conference and also at the American Animal Hospital Association Annual Forum in Phoenix. Drs. Mackin and Thomason are also scheduled to present several streaming video conference sessions demonstrating various internal medicine techniques for a live audience at the 2013 AAHA Annual Forum. Dr. Mackin recently completed the ‘Case of the Bleeding Labrador’, an on-line case presentation/continuing education course for the AAHA ‘Solve-It’ series. Dr. Mackin has been invited to speak on the main program for the upcoming ACVIM Forum in Seattle on the topic ‘Transfusion Related Babesiosis: Is It a Real Issue?’.
Publications (Past Year):
Book Chapters:
- Lathan P. Hypoadrenocorticism in Dogs. In Rand J (ed). Clinical Endocrinology of Companion Animals. Wiley, 2013.
Journal Articles:
- Fellman CL, Stokes JV, Archer TM, Pinchuk LM, Lunsford KV, Mackin AJ. (2012). Cyclosporine A Affects the In Vitro Expression of T Cell Activation-Related Molecules and Cytokines in Dogs. Veterinary Immunology and Immunopathology. 140:175-180.
- Johnson K, Mackin A. (2012). Canine Immune-Mediated Polyarthritis Part I: Pathophysiology. JAAHA. 48:12-17.
- Johnson K, Mackin A. (2012). Canine Immune-Mediated Polyarthritis Part II: Diagnosis and Treatment. JAAHA. 48:71-82.
- Mullins KB, Thomason JM, Lunsford KV, Pinchuk LM, Langston VC, Wills RW, McLaughlin RM, Mackin AJ. (2012). Effects of Carprofen, Meloxicam and Deracoxib on Platelet Function in Dog. Veterinary Anesthesia and Analgesia. 39:206-217.
- Lam N, Berent A, Weisse C, Bryan C, Mackin A, Bagley D. (2012). Endoscopic Placement of Ureteral Stents for Treatment of Congenital Bilateral Ureteral Stenosis in a Dog. JAVMA. 240:983-90.
- Thomason J, Lunsford K, Stokes J, Pinchuk L, Wills R, Langston C, Pruett S, Mackin A. (2012). The Effects of Cyclosporine on Platelet Function and Cyclooxygenase Expression in Normal Dogs. JVIM. 26:1389-1401.
- Dissanayake S, Lathan P, Mlsna T. (2012). Novel Extraction of Volatile Biomarkers from Canine Breath for Gas Chromatography Mass Spectrometry. Journal of Breath Research. 6 041001
- Lathan P. (2012). Hypothyroidism. Clinician’s Brief.
- Beall MJ, Alleman AR, Breitschwerdt EB, Cohn LA, Couto CG, Dryden MW, Guptill LC, Iazbik C, Kania SA, Lathan P, Little SE, Roy A, Sayler KA, Stillman BA, Welles EG, Wolfson W, Yabsley MJ. (2012). Seroprevalence of Ehrlichia canis, Ehrlichia chaffeensis and Ehrlichia ewingii in Dogs in North America. Parasites & Vectors. 5:29.
- Lathan P. (2012). Compounded vs Commercial PZI. Clinician’s Brief.
- Lux C, Archer T, Lunsford K. (2012). Gastroesophageal Reflux and Laryngeal Dysfunction in a Dog. JAVMA. 240:1100-3.
- Curotto S, Lunsford K, Smith W, Thomason J, Bulla C. (2012).Evidence of Selective Packaging and Different α-Granule Subtypes in Canine Platelets. Journal of Comparative Pathology. 147:499-502
- Dudley A, Thomason J, Fritz S, Grady J, Stokes J, Wills R, Pinchuk L, Mackin A, Lunsford K. (2013). Cyclooxygenase Expression and Platelet Function in Healthy Dogs Receiving Low-Dose Aspirin. JVIM. 27:141-9.
Scientific Abstracts:
- Archer T, Brinkman-Ferguson E, Dedeaux A, Geesaman B, Mackin A. (2012). Ultrasound-Guided Placement of Urethral Stents in Dogs. 30th Annual Forum of the American College of Veterinary Internal Medicine. Abstract published in JVIM.
- Fellman C, Archer T, Stokes J, Lunsford K, Mackin A. (2012). Effects of Oral Cyclosporine on Canine T-Cell Expression of IL-2 and IFN-γ Across a 12-Hour Dosing Interval. 30th Annual Forum of the American College of Veterinary Internal Medicine. Abstract published in JVIM.
- Thomason J, Lunsford K, Stokes J, Mullins K, Pinchuk L, Langston C, Wills R, McLaughlin R, Mackin A. (2012). Effects of ‘COX-2 Selective’ Non-Steroidal Anti-Inflammatory Drugs on Canine Platelet Function and Cyclooxygenase Expression. 30th Annual Forum of the American College of Veterinary Internal Medicine. Abstract published in JVIM.
- Riggs C, Archer T, Bulla C, Fellman C, Mackin A. (2012). Effect of Canine Blood Storage Conditions on Canine T- Cell Cytokine Production. 47th Annual Meeting of the American Society for Veterinary Clinical Pathology, Seattle WA. Abstract published in Vet Clin Path.
- Dissanayake S, Lathan P, Mlsna T. (2012). Identification of Volatile Biomarker Profiles of Lung Diseases in Canines Using Active SPME GCMS. Federation of Analytical Chemistry and Spectroscopy Societies, Kansas City, MO.
- Bulla SC, Geesaman B, Lunsford K, Bulla C, Thomason J. (2012). Canine Blood Platelet Count and Activation in Different Anticoagulants. 47th Annual Meeting of the American Society for Veterinary Clinical Pathology, Seattle WA. Abstract published in Vet Clin Path.
- Figueiredo AS, Bulla SC, Lunsford KV, Bulla C. (2012). Thrombopoietin Gene Expression in Healthy Dog Tissues. 47th Annual Meeting of the American Society for Veterinary Clinical Pathology, Seattle WA. Abstract published in Vet Clin Path.
- Bulla SC, Trichler S, Thomason J, Lunsford K, Bulla C. (2012). Residual Leukocyte Count in Canine Purified Platelet Samples. 47th Annual Meeting of the American Society for Veterinary Clinical Pathology, Seattle WA. Abstract published in Vet Clin Path.
- Trichler S, Bulla SC, Thomason J, Bulla C, Lunsford K. (2012). Highly Pure Platelet Isolation from Canine Whole Blood. 47th Annual Meeting of the American Society for Veterinary Clinical Pathology, Seattle WA. Abstract published in Vet Clin Path.
Research Funding (Past Year):
- Lunsford K, Thomason J, Bulla C: Aspirin as a Platelet-Releasate Modulator: Minimizing Pro-Angiogenic Priming. ACVIM Foundation Chase Away K9 Cancer. $29,750
- Archer T, Mackin A, Bulla C: The Effect of Storage Conditions on T-Cell Cytokine Production in Whole Blood Samples Exposed to Cyclosporine. MSU-CVM Office of Research and Graduate Studies. $7,610
- Pinchuk L, Archer T, Mackin A: The Role of Professional Antigen Presenting Cells in the Generation of Regulatory T-Cells in Dogs Exposed to Babesia Canis. MSU-CVM Office of Research and Graduate Studies. $8,000
- Thomason J, Lunsford K, Bulla C, Ross M, Haines J, Mackin A: Influence of Aspirin on Platelet Eicosanoid Biosynthesis. MSU-CVM Office of Research and Graduate Studies. $10,000
- Miller J, Brinkman E, Mackin A, Archer T: Cholangiography with 64-Multi-Detector Row CT in the Normal Dog and Cat. MSU-CVM ORGS House Officer Internal Grants Program. $3,000
- Seage E, Thomason J, Haines J, Lunsford K, Ross M, Bulla C, Mackin A: Alterations in Eicosanoid Biosynthesis During Low-Dose Aspirin in Normal Dogs. MSU-CVM ORGS House Officer Internal Grants Program. $2,000
- Blake R, Thomason J, Ross M, Mackin A: Eicosanoid Biosynthesis in Units of Stored Canine Packed Red Blood Cells. MSU-CVM ORGS House Officer Internal Grants Program. $2,000
- Sullivant A, Archer T, Mackin A, Cooley J, Pharr T: Identification of Histamine Receptors in the Canine Gastrointestinal Tract. MSU-CVM ORGS House Officer Internal Grants Program. $1,920
- Miller J, Brinkman-Ferguson E, Archer T, Mackin A: Cholangiography with Computed Tomography in Dogs with Hepatobiliary Disease. MSU-CVM ORGS House Officer Internal Grants Program. $1,981
- Bulla C, Lunsford K, Thomson J, Curotto S: Release of Angiogenic Factors by Canine Platelet Alpha Granules. MSU-CVM Office of Research and Graduate Studies. $9,919
- Lunsford K, Bulla C, Thomason J, Figueiredo AS: Clopidogrel as a Platelet Releasate Modulator. MSU-CVM Office of Research and Graduate Studies. $9,994
- Fellman C, Archer T, Lunsford K, Mackin A:Quantitative TR-PCR Assessment of the Immunosuppressive Effects of In-Vitro and Oral Cyclosporine on Canine T-Cell Cytokine Expression. MSU-CVM Office of Research and Graduate Studies. $2,000
- Geesaman B, Thomason J, Lunsford K, Bulla C:Comparison of Canine Platelet Counts from Blood Collected in Various Anticoagulants. MSU-CVM ORGS House Officer Internal Grants Program. $2000
- Haines J, Thomason J, Bulla C, Mackin A, Lunsford K: In-Vitro and In Vivo Assessment of Platelet Function in Canines after Administration of Low-Dose Aspirin. MSU-CVM ORGS House Officer Internal Grants Program. $2000
- Daniel A, Thomason J: Effects of Low Dose Aspirin on Platelet Function Analyzer-100® Closure Times in Dogs. Salsbury Research Grant. $1,000
