Small Animal Internal Medicine
NEWS - July 2013
The MSU-CVM Small Animal Internal Medicine service currently has five faculty members providing specialist-level clinical service to the local veterinary community. Drs. John Thomason, Andrew Mackin, Kari Lunsford, Patty Lathan and Todd Archer are regularly scheduled on clinical duty to meet local referral needs. The Medicine service routinely handles internal medicine and oncology referrals from Mississippi, Alabama and Tennessee, with occasional cases from as far away as Arkansas and Louisiana. Drs. Thomason and Lunsford have taken the lead in managing our steadily growing oncology caseload, and MSU is currently advertising for a boarded oncologist to facilitate the continued expansion of the clinical and research components of our oncology program. Dr. Taya Marquardt (WSU 2008), who was our Oncology Specialty intern from 2009 to 2010, and then a Clinical Instructor in Oncology at MSU from 2010 to 2011, has just commenced an oncology residency at Auburn University, and will then return to the MSU-CVM to join our faculty as an oncologist.
American College of Veterinary Internal Medicine:
Drs. Mackin and Thomason recently presented lectures on the main scientific program at the ACVIM Forum in Seattle, Dr. Mackin on ‘Transfusion Related Babesiosis: Is It a Real Issue?’, and Dr. Thomason on ‘Aspirin Resistance: What Do We Really Know?’. Drs. Mackin and Thomason also presented research abstracts from our research groups as posters at the Forum: ‘Use of Liposomal Clodronate to Facilitate Detection of Subclinical Infection with Babesia canis’ (Mackin, Weaver, Martin, Gunnoe, Shafer, Follows, Stokes, Pinchuk, McKenna, Birkenheuer, Dow), and ‘The Proteome of the Canine Platelet: Insights on Its Physiologic and Pathologic Roles’ (Lunsford, Curotto, Trichler, McCarthy, Nanduri, Mahajan, Thomason, Pendarvis, Bulla). Dr. Lathan, as secretary/treasurer of the Society for Comparative Endocrinology, helped run the two-day pre-Forum SCE Meeting and the SCE Business Meeting at the ACVIM Forum, and also served as a member of the ACVIM Credentials Committee. Dr. Lathan also presented a short lecture on ‘Alternative Teaching Methods for Stimulating Interest in Endocrinology’ at the Endocrine Educators Breakfast. Drs. Lathan and Mackin served as members on several ACVIM examination rating committees (General and Certifying Exams, respectively). Dr. Archer serves on the ACVIM Foundation Board of Directors, and is also a member of the Foundation’s Scientific Review Committee.
House Officers and Graduate Students:
Dr. Jill Manion completed her Medicine residency in early July, and successfully defended her Masters thesis on ‘Pharmacokinetics of Inhaled Heparin in the Dog’. Jill has just accepted a Medicine position in specialty practice in Houston, Texas. Dr. Jillian Haines now becomes our senior (third year) Medicine resident, and Dr. Claire Fellman commences the second year of her residency. Claire was recently approved by the American College of Veterinary Clinical Pharmacology to commence a dual Medicine/Pharmacology residency program. Recent Medicine/Oncology intern Dr. Alyssa Sullivant has become our first year Medicine resident. Drs. Manion and Haines both recently passed the ACVIM General Examination.
Our DVM/PhD graduate students, Shauna Trichler and Caitlin Riggs, have both passed their preliminary examinations and successfully completed the second year of their PhD programs, and have just entered the DVM professional curriculum. Shauna has been working with Drs. Lunsford, Thomason and Camilo Bulla in the Comparative Platelet Research/Diagnostic Laboratory, and Caitlin has been working on the effects of cyclosporine on of T-cell cytokine expression as measured by qRT-PCR analysis with Drs. Archer, Mackin, Fellman and Bulla.
Dr. Todd Archer, Assistant Professor in Small Animal Internal Medicine, was appointed to the ACVIM Foundation Board of Directors in 2012, and also serves on the Scientific Review Committee for the ACVIM Foundation. He also continues to serve on the Executive Board of the Mississippi Veterinary Medical Association, and recently became MVMA Vice President. Dr. Archer was recently an invited speaker at the West Virginia Veterinary Medical Association Annual Meeting and the Southeast Veterinary Conference in Myrtle Beach.
Dr. Patty Lathan, Assistant Professor in Small Animal Internal Medicine, recently provided continuing education lectures on various endocrine topics for the Southeast Veterinary Conference in Myrtle Beach. Dr. Lathan serves on the MSU Cultural Competencies Task Force, and recently participated in Southeastern Veterinary Student ‘Diversity Matters’ Symposium at the Virginia-Maryland College of Veterinary Medicine.
Dr. Kari Lunsford recently successfully went through MSU’s promotion and tenure process, and is now Associate Professor in Small Animal Internal Medicine. Dr. Lunsford serves as Program Coordinator of the MSU-CVM Translational Biomedical Research center (TRBc), and is working with Dr. Bulla in developing comparative and translational research programs centering around the work being done in the Comparative Angiogenesis and Comparative Platelet Investigation Laboratories. Drs. Lunsford and Bulla are working on identifying important proteins involved in cancer metastasis and progression that may serve as markers for early diagnosis of cancer and disease progression.
Dr. John Thomason, Assistant Professor in Small Animal Internal Medicine, participated in the AVMA Small Animal Medicine Review Committee for the ECFVG Examination. Drs. Thomason and Mackin also recently presented several streaming video conference sessions demonstrating various internal medicine techniques for a live audience at the 2013 AAHA Annual Forum. Dr. Thomason continues to serve as course coordinator for the popular Practical Clinical Oncology senior elective course.
Dr. Andrew Mackin, Professor and Dr. Hugh G. Ward Endowed Chair of Small Animal Veterinary Medicine, has recently spoken at the Western Veterinary Conference in Las Vegas and at the American Animal Hospital Association Annual Forum in Phoenix. Dr. Mackin is also scheduled to speak at the inaugural Gulf-Atlantic Veterinary Conference in Florida in October. Outside of the CVM, Dr. Mackin is team manager of the Starkville Soccer Association Bulldogs U17 Boys soccer team, who recently became Mississippi state champions.
Publications (Past Year):
- Lathan P. Hypoadrenocorticism in Dogs. In Rand J (ed). Clinical Endocrinology of Companion Animals. Wiley, 2013.
- Fellman CL, Stokes JV, Archer TM, Pinchuk LM, Lunsford KV, Mackin AJ. (2012). Cyclosporine A Affects the In Vitro Expression of T Cell Activation-Related Molecules and Cytokines in Dogs. Veterinary Immunology and Immunopathology. 140:175-180.
- Johnson K, Mackin A. (2012). Canine Immune-Mediated Polyarthritis Part I: Pathophysiology. JAAHA. 48:12-17.
- Johnson K, Mackin A. (2012). Canine Immune-Mediated Polyarthritis Part II: Diagnosis and Treatment. JAAHA. 48:71-82.
- Mullins KB, Thomason JM, Lunsford KV, Pinchuk LM, Langston VC, Wills RW, McLaughlin RM, Mackin AJ. (2012). Effects of Carprofen, Meloxicam and Deracoxib on Platelet Function in Dog. Veterinary Anesthesia and Analgesia. 39:206-217.
- Lam N, Berent A, Weisse C, Bryan C, Mackin A, Bagley D. (2012). Endoscopic Placement of Ureteral Stents for Treatment of Congenital Bilateral Ureteral Stenosis in a Dog. JAVMA. 240:983-90.
- Thomason J, Lunsford K, Stokes J, Pinchuk L, Wills R, Langston C, Pruett S, Mackin A. (2012). The Effects of Cyclosporine on Platelet Function and Cyclooxygenase Expression in Normal Dogs. JVIM. 26:1389-1401.
- Dissanayake S, Lathan P, Mlsna T. (2012). Novel Extraction of Volatile Biomarkers from Canine Breath for Gas Chromatography Mass Spectrometry. Journal of Breath Research. 6 041001
- Lathan P. (2012). Hypothyroidism. Clinician’s Brief.
- Beall MJ, Alleman AR, Breitschwerdt EB, Cohn LA, Couto CG, Dryden MW, Guptill LC, Iazbik C, Kania SA, Lathan P, Little SE, Roy A, Sayler KA, Stillman BA, Welles EG, Wolfson W, Yabsley MJ. (2012). Seroprevalence of Ehrlichia canis, Ehrlichia chaffeensis and Ehrlichia ewingii in Dogs in North America. Parasites & Vectors. 5:29.
- Lathan P. (2012). Compounded vs Commercial PZI. Clinician’s Brief.
- Lux C, Archer T, Lunsford K. (2012). Gastroesophageal Reflux and Laryngeal Dysfunction in a Dog. JAVMA. 240:1100-3.
- Curotto S, Lunsford K, Smith W, Thomason J, Bulla C. (2012).Evidence of Selective Packaging and Different α-Granule Subtypes in Canine Platelets. Journal of Comparative Pathology. 147:499-502
- Dudley A, Thomason J, Fritz S, Grady J, Stokes J, Wills R, Pinchuk L, Mackin A, Lunsford K. (2013). Cyclooxygenase Expression and Platelet Function in Healthy Dogs Receiving Low-Dose Aspirin. JVIM. 27:141-9.
- Archer T, Mackin, A. (2013). Diagnosis of Immune-Mediated Hemolytic Anemia. Today’s Veterinary Practice. July/August: 30-34.
- Trichler S, Bulla S, Thomason J, Lunsford K, Bulla C. (2013). Ultra Pure Platelet Isolation from Canine Whole Blood. BMC Veterinary Research. 9:144
- Figueiredo AS, Bulla SC, Lunsford KV, Bulla C. (2013). Expression of the Thrombopoietin Gene in Tissues from Healthy Dogs. J Comp Pathol. May 7. pii: S0021-9975(13)00054-6. doi: 10.1016/j.jcpa.2013.03.005. [Epub ahead of print]
- Figueiredo AS, Garcia-Crescioni HJ, Bulla SC, Ross MK, McIntosh C, Lunsford K, Bulla C. (2013). Suppression of Vascular Endothelial Growth Factor Expression by Cannabinoids in a Canine Osteosarcoma Cell Line. Veterinary Medicine: Research and Reports. 4:31–34
- Archer T, Brinkman-Ferguson E, Dedeaux A, Geesaman B, Mackin A. (2012). Ultrasound-Guided Placement of Urethral Stents in Dogs. 30th Annual Forum of the American College of Veterinary Internal Medicine. Abstract published in JVIM.
- Fellman C, Archer T, Stokes J, Lunsford K, Mackin A. (2012). Effects of Oral Cyclosporine on Canine T-Cell Expression of IL-2 and IFN-γ Across a 12-Hour Dosing Interval. 30th Annual Forum of the American College of Veterinary Internal Medicine. Abstract published in JVIM.
- Thomason J, Lunsford K, Stokes J, Mullins K, Pinchuk L, Langston C, Wills R, McLaughlin R, Mackin A. (2012). Effects of ‘COX-2 Selective’ Non-Steroidal Anti-Inflammatory Drugs on Canine Platelet Function and Cyclooxygenase Expression. 30th Annual Forum of the American College of Veterinary Internal Medicine. Abstract published in JVIM.
- Riggs C, Archer T, Bulla C, Fellman C, Mackin A. (2012). Effect of Canine Blood Storage Conditions on Canine T- Cell Cytokine Production. 47th Annual Meeting of the American Society for Veterinary Clinical Pathology, Seattle WA. Abstract published in Vet Clin Path.
- Dissanayake S, Lathan P, Mlsna T. (2012). Identification of Volatile Biomarker Profiles of Lung Diseases in Canines Using Active SPME GCMS. Federation of Analytical Chemistry and Spectroscopy Societies, Kansas City, MO.
- Bulla SC, Geesaman B, Lunsford K, Bulla C, Thomason J. (2012). Canine Blood Platelet Count and Activation in Different Anticoagulants. 47th Annual Meeting of the American Society for Veterinary Clinical Pathology, Seattle WA. Abstract published in Vet Clin Path.
- Figueiredo AS, Bulla SC, Lunsford KV, Bulla C. (2012). Thrombopoietin Gene Expression in Healthy Dog Tissues. 47th Annual Meeting of the American Society for Veterinary Clinical Pathology, Seattle WA. Abstract published in Vet Clin Path.
- Bulla SC, Trichler S, Thomason J, Lunsford K, Bulla C. (2012). Residual Leukocyte Count in Canine Purified Platelet Samples. 47th Annual Meeting of the American Society for Veterinary Clinical Pathology, Seattle WA. Abstract published in Vet Clin Path.
- Trichler S, Bulla SC, Thomason J, Bulla C, Lunsford K. (2012). Highly Pure Platelet Isolation from Canine Whole Blood. 47th Annual Meeting of the American Society for Veterinary Clinical Pathology, Seattle WA. Abstract published in Vet Clin Path.
- Mackin A, Weaver K, Martin P, Gunnoe G, Shafer L, Follows J, Stokes J, Pinchuk L, McKenna M, Birkenheuer A, Dow S. (2013). Use of Liposomal Clodronate to Facilitate Detection of Subclinical Infection with Babesia canis in Greyhounds. 31st Annual Forum of the ACVIM. Abstract published in JVIM.
- Lunsford K, Bulla SC, Trichler S, McCarthy F, Nanduri B, Mahajan N, Thomason J, Pendarvis K, Bulla C. The Proteome of the Canine Platelet: Insights on Its Physiologic and Pathologic Roles. 31st Annual Forum of the ACVIM. Abstract published in JVIM.
Research Funding (Past Year):
- Lunsford K, Thomason J, Bulla C: Aspirin as a Platelet-Releasate Modulator: Minimizing Pro-Angiogenic Priming. ACVIM Foundation Chase Away K9 Cancer. $29,750
- Archer T, Mackin A, Bulla C: The Effect of Storage Conditions on T-Cell Cytokine Production in Whole Blood Samples Exposed to Cyclosporine. MSU-CVM Office of Research and Graduate Studies. $7,610
- Pinchuk L, Archer T, Mackin A: The Role of Professional Antigen Presenting Cells in the Generation of Regulatory T-Cells in Dogs Exposed to Babesia Canis. MSU-CVM Office of Research and Graduate Studies. $8,000
- Thomason J, Lunsford K, Bulla C, Ross M, Haines J, Mackin A: Influence of Aspirin on Platelet Eicosanoid Biosynthesis. MSU-CVM Office of Research and Graduate Studies. $10,000
- Miller J, Brinkman E, Mackin A, Archer T: Cholangiography with 64-Multi-Detector Row CT in the Normal Dog and Cat. MSU-CVM ORGS House Officer Internal Grants Program. $3,000
- Seage E, Thomason J, Haines J, Lunsford K, Ross M, Bulla C, Mackin A: Alterations in Eicosanoid Biosynthesis During Low-Dose Aspirin in Normal Dogs. MSU-CVM ORGS House Officer Internal Grants Program. $2,000
- Blake R, Thomason J, Ross M, Mackin A: Eicosanoid Biosynthesis in Units of Stored Canine Packed Red Blood Cells. MSU-CVM ORGS House Officer Internal Grants Program. $2,000
- Sullivant A, Archer T, Mackin A, Cooley J, Pharr T: Identification of Histamine Receptors in the Canine Gastrointestinal Tract. MSU-CVM ORGS House Officer Internal Grants Program. $1,920
- Miller J, Brinkman-Ferguson E, Archer T, Mackin A: Cholangiography with Computed Tomography in Dogs with Hepatobiliary Disease. MSU-CVM ORGS House Officer Internal Grants Program. $1,981
- Bulla C, Lunsford K, Thomson J, Curotto S: Release of Angiogenic Factors by Canine Platelet Alpha Granules. MSU-CVM Office of Research and Graduate Studies. $9,919
- Lunsford K, Bulla C, Thomason J, Figueiredo AS: Clopidogrel as a Platelet Releasate Modulator. MSU-CVM Office of Research and Graduate Studies. $9,994
- Fellman C, Archer T, Lunsford K, Mackin A:Quantitative TR-PCR Assessment of the Immunosuppressive Effects of In-Vitro and Oral Cyclosporine on Canine T-Cell Cytokine Expression. MSU-CVM Office of Research and Graduate Studies. $2,000
- Geesaman B, Thomason J, Lunsford K, Bulla C:Comparison of Canine Platelet Counts from Blood Collected in Various Anticoagulants. MSU-CVM ORGS House Officer Internal Grants Program. $2000
- Haines J, Thomason J, Bulla C, Mackin A, Lunsford K: In-Vitro and In Vivo Assessment of Platelet Function in Canines after Administration of Low-Dose Aspirin. MSU-CVM ORGS House Officer Internal Grants Program. $2000
- Daniel A, Thomason J: Effects of Low Dose Aspirin on Platelet Function Analyzer-100® Closure Times in Dogs. Salsbury Research Grant. $1,000
- Archer T, Thomason J, Fellman C, Pinchuk L, Stokes J, Mackin A: In-vivo Effects of Aspirin and Cyclosporine on Regulatory T-cells and T-Cell Cytokine Production in Healthy Dogs. MSU-CVM ORGS. $10,000
- Thomason J, Archer T, Ross M, Bulla C, Mackin A: Immunosuppressive and Anti-Platelet Effects of Pentoxifylline in Healthy Dogs. MSU-CVM ORGS. $10,000
- Lathan P, Stewart K: The Use of Glargine Insulin Pens in Cats. Nestle-Purina. $2,000