Center for Environmental Health Sciences
Research Projects
Effect of Organophosphate Exposure on Cholesteryl Ester Hydrolase—Administrative Supplement (sponsored by NIH)
This administrative supplement will extend the aims of our parent grant to study the effects of organophosphate (OP) pesticides on other genes and proteins besides CES1 that participate in cholesterol metabolism. The effects of OP pesticides on the abundance and activities of these proteins in cholesterol-loaded human THP1 macrophages using RT-PCR, western blotting, and functional assays (e.g., cholesterol efflux and cholesterol mass determination) will be examined.
