Development of Paraoxonase (PON) Enhancers to Accelerate the Efficiency of PON-Mediated Nerve Agent Hydrolysis
Paraoxonase (PON) is an enzyme associated with the serum high density lipoprotein particle and its activity is protective of cardiovascular health. PON also has a limited ability to destroy organophosphates, such as nerve agents. This project seeks nucleophilic small molecules that can enhance the PON-mediated destruction of organophosphates. Such nucleophiles may have potential as antidotes to protect against nerve agent intoxication.