Publications
Research Articles
Scott, V.L., L.A. Shack, J.B. Eells, P.L. Ryan, J.R. Donaldson and K. S. Coats. (2011) Immunomodulator expression in trophoblasts from the feline immunodeficiency virus (FIV)-infected cat. Virology Journal. Jul 5; 8:336. PubMed link
Eells, J.B. and T.W. Brown. (2009) Repeated developmental exposure to chlorpyrifos and methyl parathion causes persistent alterations in nicotinic acetylcholine subunit RNA expression with chlorpyrifos altering dopamine metabolite levels. Neurotoxicol. Teratol. 31:90-103. PubMed link
Moore, T.M., Brown, T., Cade, M & Eells, J.B. (2008) Alterations in amphetamine stimulated dopamine overflow due to the Nurr1-null heterozygous genotype and post-weaning isolation. Synapse. 62:764-774. PubMed link
Gil, M., McKinney, C., Lee, M., Eells, J.B., Phyillaier, M.A., & Nikodem, V.M. (2007) Regulation of GTP-cyclohydrolase gene expression by orphan receptor Nurr1 in cell culture and in vivo. J. Neurochem. 101, 142-50. PubMed link
Eells, J.B., Misler, J.A., & Nikodem, V.M. (2006) Reduced tyrosine hydroxylase activity concurrent with reduced tyrosine hydroxylase and GTP cyclohydrolase mRNA expression in Nurr1-null heterozygous mice. Brain Res Bull. 70, 186-195. PubMed link
Eells, J.B., Misler, J.A., & Nikodem, V.M. (2006) Isolation-rearing disrupts prepulse inhibition in Nurr1-null heterozygous mice. Neuroscience. 140, 1117-1126. PubMed link
Eells J.B., R.W. Clough, R.A. Browning & P.C. Jobe. (2004) Comparative fos immunoreactivity in the brain after forebrain, brainstem, or combined seizures induced by electroshock, pentylenetetrazol, focally induced and audiogenic seizures in rats. Neuroscience. 123, 279-292. PubMed link
Eells, J.B., Lipska, B.K., Yeung, S.K., Misler, J.A., & Nikodem, V.M. (2002) Nurr1-null heterozygous mice have reduced mesolimbic and mesocortical dopamine levels and increased stress-induced locomotor activity. Behav. Brain Res. 136, 267-275. PubMed link
Eells, J.B., Yeung, S.K., & Nikodem, V.M. (2002) Dopamine neurons heterozygous for the Nurr1-null allele have reduced survival in vitro. Neurosci. Res. Comm. 30, 173-183.
Yu, X., Shacka, J.J., Eells, J.B., Carlos, S.Q., Przygodzki, R.M., Beleslin-Cokic, B., Lin, C.S., Nikodem, V.M., Hempstead, B., Flanders, K.C., Contantini, F., & Noguchi, C.T. (2002) Erythropoietin receptor signaling is required for normal brain development. Development. 129, 505-516 PubMed link
Eells, J.B., Rives, J.B., Yeung, S.K., & Nikodem, V.M. (2001) In vitro regulated expression of tyrosine hydroxylase in ventral midbrain neurons from Nurr1-null mouse pups. J. Neurosci. Res. 64, 322-330. PubMed link
Eells, J.B., Clough, R.W., & Browning, R.A. (2000) Fos expression and 2-deoxyglucose uptake following seizures in developing genetically epilepsy-prone rats. Brain Res Bull. 52, 379-389. PubMed link
Eells J.B., Clough, R.W., & Browning, R.A. (1998) Expression of Fos in the superior lateral subdivision of the lateral parabrachial (LPBsl) area after generalized tonic seizures in rats. Brain Res. Bull. 47, 155-161 PubMed link
Clough, R.W., Peterson, B.R., Steenbergen, J.L., Jobe, P.C., Eells, J.B., Browning, R.A., & Mishra, P.K. (1998) Neurite extension of developing noradrenergic neurons is impaired in genetically epilepsy-prone rats (GEPR-3s): an in vitro study on the locus coeruleus. Epilepsy Res. 29, 135-146 PubMed link
Eells, J.B., Clough, R.W., & Jobe, P.C. (1997) Fos immunoreactivity in locus coeruleus neurons following audiogenic seizure in the genetically epilepsy-prone rat: comparison to electroshock and pentylenetetrazol seizure models. Neurosci. Lett., 233, 21-24. PubMed link
Clough, R.W., Eells, J.B., Browning, R.A., & Jobe, P.C. (1997) Seizures and proto-oncogene expression of fos in the brain of adult genetically epilepsy-prone rats (GEPRs). Exp. Neurol., 146, 341-353. PubMed link
Clough, R., Statnick, M., Maring-Smith, M., Wang, C., Eells, J., Browning, R., Dailey, J., & Jobe, P. (1996) Fetal raphe-tissue transplants attenuate exacerbated seizure severity in GEPRs. Neuroreport, 8, 341-346 PubMed link
Gitz, D.L., Eells, J.B., & Pennock, D.G. (1993) The dcc mutation affects ciliary length in Tetrahymena thermophila. J. Euk. Micobio., 40, 668-676. PubMed link
Review Articles
Eells, J.B. (2003) The control of dopamine neuron development, function and survival: Insights from transgenic mice and the relevance to human disease. Cur. Med. Chem. 10, 857-870 PubMed link
Eells, J.B., Witta, J., Otridge, J.B., Zuffova, E., & Nikodem, V.M. (2000) Structure and function of the Nur77 subfamily, a unique class of hormone nuclear receptors. Cur. Genomics. 1, 135-152.
Research Articles in Preparation
Eells J.B., Taylor, M.A., Bell, A.S., Kummari, E, Guo-Ross, S. (2011) Region specific effects of aging and the Nurr1-null heterozygous genotype on dopamine neurotransmission.
Eells J.B., Sisk S, and Guo-Ross, S. (2011) Nur (Nurr1 and Nur77) expression is dynamically regulated in mesolimbic dopamine neurons.
Invited Presentations
Eells, J.B. “The genetic control of dopamine neuron function and its relevance to schizophrenia.” The Institute for Neurocognitive Science and Technology (INST) Colloquium Series, Mississippi State University. April 25th, 2006.
Eells, J.B. "Genetic control of dopamine neurons: the function of the transcription factor Nurr1”Department of Biochemistry and Molecular Biology Seminar Series, Mississippi State University. October 13th, 2004.
Eells, J.B. Using gene expression profiling (GEXP) chemistry on amplified RNA. Beckman Coulter Symposium 2007. September 13th, 2007.
Eells, J.B. GenomeLab GeXP multiplex gene expression analysis of nanogram and pictogram total RNAs from LCM selected neurological tissues. Beckman Coulter International Webinar, November 15th, 2007 (www.beckman.com/resourcecenter.labresources/geneticanalysis/ceq/seminar_list.asp )
Abstracts
Eells J.B. (2010) The interaction of aging and function of the transcription factor Nurr1 on dopamine neurotransmission. BITs 1st Annual World Congress of NeuroTalk 2010, June 25-28, 2010. Singapore EXPO, Singapore.
Sisk, S., Guo-Ross, S. & Eells, J.B. (2010) Effect of the Nurr1-null heterozygote genotype on the D2 autoreceptor regulation of dopamine neurotransmission. 2010 Annual Meeting of the South Central Chapter of the Society of Toxicology, October 14-15 – Mississippi State, Mississippi.
Eells, J.B. and Moore, T.M. (2010) Nurr1-null heterozygous mice and post-weaning isolation: a combined genetic-developmental animal model for schizophrenia. Neuroscience and Behavior Research Day, University of Mississippi Medical Center, December 1, 2010.
Moore, T.M., Sisk, S., Bell, A., Guo-Ross, S, & Eells, J.B. (2010) Dopamine neuron gene expression in mesocortical, mesoaccumbens and nigrostriatal dopamine neurons
isolated using laser capture microdissection. Soc. Neurosci. Abstr. 61.7.
Kummari, E., Guo-Ross, S., Peavy, P., & Eells, J.B. (2010) Region specific dopamine deficits result from the combination of the Nurr1-null heterozygous genotype
and aging. Soc. Neurosci. Abstr. 52.9.
Sisk, S. S. Guo-Ross, S. & Eells, J.B. (2010). Regulation of Nurr1 expression in dopamine neurons. MSU Undergraduate Research Symposium. July 29.
McShane, S. Guo-Ross, S. & Eells, J.B. (2010). Effect of in vivo reduction of nurr1 expression in Nurr1-null heterozygous (+/-) mice on nigrostriatal dopamine neurotransmission and dopamine neuron survival. Merck/Merial NIH National Veterinarian Scholars Symposium, University of Georgia, Athens, GA.
Eells, J.B. & Bell, A. (2009) Nigrostriatal dopamine neurotransmission: effects of aging and the Nurr1-null heterozygous genotype. Soc. Neurosci. Abstr. 531.8.
Moore, T.M. & Eells, J.B. (2009) Direct stimulation of nigrostriatal dopamine neurons via reverse microdialysis fordopamine neuron isolation with laser capture microdissection and gene expression analysis. Soc. Neurosci. Abstr. 828.24
Eells, J.B., & Wilcots, J.I. (2008) Determination of the mechanisms involved in the induction of nuclear receptors in the midbrain and investigation of the related neurochemical changes involved. Soc. Neurosci. Abstr. 832.14
Carlsen, J. & Eells, J.B. (2008) Intranigral injection of rotenone and increased susceptibility in Nurr1 heterozygous mice to neurodegeneration and dopaminergic response in the substantia nigra and striatum. Soc. Neurosci. Abstr. 742.1.
Moore, T.M. & Eells, J.B. (2007) Nurr1 mRNA expression in dopamine neurons isolated with laser capture microdissection. Merck/Merial NIH National Veterinarian Scholars Symposium, Michigan State University, East Lansing, Michigan.
Carlsen, J., Brown, T.W. & Eells, J.B. (2008) Altered dopamine levels and neurodegeneration in the substantia nigra in response to intranigral injection of rotenone in mice. Toxicologist. 2039.
Eells, J.B. (2008) Gene express profiling multiplex quantitative PCR on amplified RNA. Toxicologist. 1836
Wilcots, J.I., Brown, T.W., & Eells, J.B., (2007) Determination of induction of Nur77 (Nr4a1) and NOR-1 (Nr4a2) in dopamine neurons. Soc. Neurosci. Abstr. 119.9.
Eells, J.B., Brown, T.W. &, Moore, T.W. (2007) Combining quantitative gene express profiling with laser capture microdissection of dopamine neurons. Soc. Neurosci. Abstr. 313.16.
Moore, T.M., Brown, T.W. & Eells, J.B. (2007) Identification of mesocortical dopamine neurons for laser capture microdissection. Soc. Neurosci. Abstr. 313.15.
Eells, J.B., Hoffman, S., & Brown, T. (2007) Rotenone toxicity in Nurr1-null heterozygous and wild-type mice. Toxicologist. 899.
Purvis, K.J., & Eells J.B. (2007) Identification of mesocortical dopamine neurons for isolation with laser capture microdissection, Merck/Merial NIH National Veterinarian Scholars Symposium, National Institutes of Health, Bethesda, MD.
Eells, J.B., Brown, T. W., Oades, K., Carhart, J., & Vansant, G. (2006). Quantitative gene eXpress profiling (GeXP) in dopamine neurons after paraquat treatment. Soc. Neurosci. Abstr. 220.9.
Gopalakrishnan, S., Brown, T. W., Eells, J.B. (2006). Effect of paraquat on dopamine neuron survival and function in Nurr1-null heterozygous mice. Soc. Neurosci. Abstr. 581.18.
Moore, T. M., Brown, T.W. & Eells, J. B. (2006). Altered dopamine levels in the nucleus accumbens of isolated and group reared nurr1-null heterozygous mice following administration of amphetamine by microdialysis. Soc. Neurosci. Abs. 589.15.
Moore, T, Brown, T.W. & Eells, J.B. (2006) Altered dopamine levels in the nucleus accumbens of isolated and group reared Nurr1-null heterozygous mice following administration of amphetamine by micordialysis. Graduate Student Assoc. 4th Annual Research Symposium. Mississippi State University.
Eells, J.B. & Brown, T.W. (2006) Chronic developmental exposure to organophosphates elevates dopamine levels and alters nicotinic acetylcholine subunit RNA expression. Toxicologist. 1442.
Hoffman, S., Brown, T.W. & Eells, J.B. (2006) Rotenone induced dopamine neuron degeneration in Nurr1-null heterozygous and wild-type mice. Merck/Merial NIH National Veterinarian Scholars Symposium, Louisiana State University, Shreveport, LA.
Eells, J.B. & Brown, T.W. (2006) Chronic developmental exposure to organophosphates elevates dopamine levels and alters nicotinic acetylcholine subunit RNA expression. Toxicologist. 1442.
Moore, T.M., Brown, T.W. & Eells, J.B. (2006) Altered Dopamine Levels in the Nucleus Accumbens of Isolated and Group Reared Nurr1-Null Heterozygous Mice Following Administration of Amphetamine by Microdialysis. INST Research Forum, Mississippi State University.
Moore, T, Brown, T.W. & Eells, J.B. (2006) Altered dopamine levels in the nucleus accumbens of isolated and group reared Nurr1-null heterozygous mice following administration of amphetamine by micordialysis. Graduate Student Assoc. 4th Annual Research Symposium. Mississippi State University.
Eells, J.B. & Brown, T.W. (2005) Altered amphetamine stimulated dopamine release in the striatum of Nurr1-null heterozygous mice. Soc. Neurosci. Abstr. 299.11.
Cade, M., Brown, T.W. & Eells, J.B. (2005) Changes in dopamine release in the striatum of Nurr1-null heterozygous transgenic mice following administration of amphetamine by microdialysis. Merck/Merial NIH National Veterinarian Scholars Symposium, University of Georgia, Athens, GA
Eells, J.B. & Brown, T.W. (2005) Altered amphetamine stimulated dopamine release in the striatum of Nurr1-null heterozygous mice. Soc. Neurosci. Abstr. 299.11.
Eells, J.B. & Nikodem, V.M. (2004) Postnatal isolation disrupts sensorimotor gating and alters dopamine levels in the prefrontal cortex of Nurr1-null heterozygous mice. Soc. Neurosci. Abstr. 1023.17
Virgous, C. & Eells, J.B. (2004) Using in vivo Microdialysis and HPLC to Measure Dopamine Levels in the Nurr-1 Mouse Brain. All College Day Presentation, CVM, Mississippi State University.
Eells, J.B., Misler, J.A., & Nikodem, V.M. (2003) Reduced tyrosine hydroxylase activity and mRNA expression in Nurr1-null heterozygous mice. Soc. Neurosci. Abstr. 157.6.
Eells, J.B., Misler, J.A., & Nikodem, V.M. (2002) Sensory motor gating is disrupted in Nurr1-null heterozygous mice by social isolation. Soc. Neursci. Abstr. 305.12.
Eells, J.B., Yeung, S.K., Lipska, B.K. & Nikodem, V.M. (2001) Increased locomotor activity in Nurr1-null heterozygous mice. Soc. Neursci. Abstr. 297.4.
Eells, J.B., Rives, J.B., & Nikodem, V.M. (2000) In vitro expression of tyrosine hydroxylase in ventral midbrain neurons from Nurr1 knockout pups. Soc. Neursci. Abstr. 600.26.
Witta, J., Baffi, J.S., Palkovits, M., Mezey, É., Castillo, S., Yang, S., Eells, J., & Nikodem, V.M. (1999) Dopamine (DA) neuron precursors in the ventral midbrain arrest from terminal differentiation, express general neuronal markers and innervate the striatum in Nurr1 disrupted mice. Soc. Neurosci. Abstr., 487.1.
Mohney, R.P., Eells, J.B., & Hong, J.S. (1998) Expression of proenkephalin mRNA in rat olfactory bulb following kainic acid treatment. Soc. Neurosci. Abstr., 816.6.
Eells, J.B., Browning, R.A., & Clough, R.W. (1997) Differential profiles of Fos expression between forebrain-evoked and brainstem-evoked seizures in rats: is the ciruitry separable. Soc. Neursci. Abstr., 661.3.
Clough, R.W., Peterson, B.R., Eells, J.B., Browning, R.A., Steenbergen, J.L., Mishra, P.K., & Jobe, P.C. (1997) Noradrenergic abnormalities in genetically epilepsy-prone rats may result from deficient arborization of developing locus coeruleus (LC) neurons: an in vitro study. Soc. Neurosci. Abstr., 661.7.
Clough, R.W, Peterson, B.R., Eells, J.B., Browning, R.A., Steenbergen, J.L., Mishra, P.K., & Jobe, P.C. (1996) Neurite arborization of fetal locus coeruleus (LC) neurons in vitro: Analysis of substrates, cytosine-arabinofuranoside and co-cultures in preparation for studies on epilepsy. Soc. Neurosci. Abstr., 819.1.
Eells, JB., Browning, R.A. & Clough, R.W. (1996) Identification of a distinct neuronal population in the dorsal pontine tegmentum expressing Fos-like immunoreactivity induced by brainstem-evoked seizure. Soc. Neurosci. Abstr., 821.12.
Eells, J.B., Clough, R.W., Jobe, P.C., & Browning, R.A. (1995) Coincident maturation of audiogenic seizure propensity and Fos activation patterns in developing genetically epilepsy-prone rats. Soc. Neurosci. Abstr., 770.5.
Clough, R.W., Eells, J.B., Jobe, P.C., & Browning, R.A. (1995) Audiogenic seizures induce expression of Fos in the nucleus locus coeruleus of genetically epilepsy prone rats. Soc. Neurosci. Abstr., 770.4.
Eells, J.B., Clough, R.W., & Browning, R.A. (1995) Comparison of Fos immunoreactivity following generalized forebrain clonic seizures and brainstem tonic seizures. SIUC School of Medicine Sigma Xi Combined Research Symposium.
Eells, J.B., Clough, R.W., Maring, M.L., Browning, R.A., & Smith, D.C. (1994) Proto-oncogene (c-Fos) expression in the brain after audiogenic-, electroshock-, and chemically induced seizures in normal and genetically epilepsy-prone rats. Soc. Neurosci. Abstr., 172.14.